In vivo metabolism of testosterone-3H in R-3327, an androgen-sensitive rat prostatic adenocarcinoma.

A spontaneous prostatic adenocarcinoma (R-3327) of a Copenhagen rat has been maintained for 14 generations by s.c. transplantations to Copenhagen and Fi hybrid hosts. The tumor remains histologically a well-differentiated ade nocarcinoma. In order to study the role of gonadal hor mones in this system, tumor expiants were inoculated to intact males, castrated males, and intact females, and the growth of the expiants was followed for 5 months. The tumor grew well only in intact males: it grew moderately well in intact females and did not grow in castrates. The metabolism of testosterone-3H by this tumor was studied by